This information is current as Development Locus Activation in Pre - B Cell κ Light Chain IFN Regulatory Factor

This information is current as Development Locus Activation in Pre - B Cell κ Light Chain IFN Regulatory Factor 4 and 8 Promote Ig

Development Locus Activation in Pre - B Cell κ Light Chain IFN Regulatory Factor

Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions

During B cell development, the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin κ light chain (Igκ) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline V(κ) transcription. To investigate whether pre-BCR signaling modulates V(κ) accessibility through enhancer-mediat...

Pumping the breaks on B cell development

The assembly of immunoglobulin genes occurs in ordered waves during B cell development. The heavy chain (Igh) locus generally recombines first, and each allele has at most one chance to undergo a productive rearrangement. Subsequently, at the κ (Igk) locus, individual alleles can undergo sequential rounds of rearrangement , permitting different light-heavy chain combinations to be tested until ...

IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development.

B-lymphocyte development involves sequential DNA rearrangements of immunoglobulin (Ig) heavy (mu) and light (kappa, lambda) chain loci and is dependent on transient expression of mu containing pre-antigen receptor complexes (pre-BCR). To date, genetic analysis has not identified transcription factors that coordinate the pre-B-to-B transition. We demonstrate that the related interferon regulator...